TY - GEN AU - Bohn,L M AU - Gainetdinov,R R AU - Lin,F T AU - Lefkowitz,R J AU - Caron,M G TI - Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence SN - 0028-0836 PY - 2001///0111 KW - Adenylyl Cyclases KW - metabolism KW - Analgesics, Opioid KW - pharmacology KW - Animals KW - Arrestins KW - physiology KW - Brain Stem KW - Drug Implants KW - Drug Tolerance KW - GTP-Binding Proteins KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - Membranes KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Morphine KW - Morphine Dependence KW - Mutation KW - Receptors, Opioid, mu KW - beta-Arrestin 2 KW - beta-Arrestins N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/35047086 ER -