Cole, P D High-dose methotrexate is lethal to rats. Why give it to children? [electronic resource] - Pediatric hematology and oncology Dec 2000 - 609-13 p. digital Publication Type: Comment; Editorial ISSN: 0888-0018 Standard No.: 10.1080/08880010050211312 doi Subjects--Topical Terms: AnimalsAntimetabolites, Antineoplastic--administration & dosageChildHumansMethotrexate--administration & dosageNeoplasms--drug therapyOsteosarcoma--drug therapyPrecursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapyRats