TY  - GEN
AU  - Thuresson,E D
AU  - Lakkides,K M
AU  - Rieke,C J
AU  - Sun,Y
AU  - Wingerd,B A
AU  - Micielli,R
AU  - Mulichak,A M
AU  - Malkowski,M G
AU  - Garavito,R M
AU  - Smith,W L
TI  - Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid
SN  - 0021-9258
PY  - 2001///0510
KW  - Amino Acids
KW  - chemistry
KW  - Animals
KW  - Arachidonic Acid
KW  - metabolism
KW  - Binding Sites
KW  - Blotting, Western
KW  - COS Cells
KW  - Catalysis
KW  - Cell Membrane
KW  - Chromatography, High Pressure Liquid
KW  - Chromatography, Thin Layer
KW  - Cyclooxygenase 1
KW  - DNA Mutational Analysis
KW  - Dose-Response Relationship, Drug
KW  - Esters
KW  - Hydrogen
KW  - Isoenzymes
KW  - Kinetics
KW  - Leucine
KW  - Methionine
KW  - Models, Biological
KW  - Models, Chemical
KW  - Oxygen
KW  - Peroxidase
KW  - Phenylalanine
KW  - Prostaglandin-Endoperoxide Synthases
KW  - Protein Binding
KW  - Protein Conformation
KW  - Protein Structure, Tertiary
KW  - Sheep
KW  - Time Factors
KW  - Transfection
KW  - Tryptophan
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1074/jbc.M009377200
ER  -