Bombardier, C

Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. [electronic resource] - The New England journal of medicine 11 2000 - 1520-8, 2 p following 1528 p. digital

Publication Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

0028-4793

10.1056/NEJM200011233432103 doi


Adult
Arthritis, Rheumatoid--drug therapy
Cardiovascular Diseases--mortality
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors--therapeutic use
Duodenal Obstruction--chemically induced
Female
Gastric Outlet Obstruction--chemically induced
Gastrointestinal Diseases--chemically induced
Gastrointestinal Hemorrhage--chemically induced
Humans
Isoenzymes--antagonists & inhibitors
Lactones--adverse effects
Male
Membrane Proteins
Middle Aged
Naproxen--adverse effects
Peptic Ulcer--chemically induced
Proportional Hazards Models
Prostaglandin-Endoperoxide Synthases
Sulfones