Prostaglandin E2 selectively enhances the IgE-mediated production of IL-6 and granulocyte-macrophage colony-stimulating factor by mast cells through an EP1/EP3-dependent mechanism. [electronic resource]
- Journal of immunology (Baltimore, Md. : 1950) Dec 2000
- 6545-52 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-1767
10.4049/jimmunol.165.11.6545 doi
Adjuvants, Immunologic--physiology Animals Bone Marrow Cells--immunology Cell Degranulation--immunology Cell Line Cyclic AMP--physiology Cytokines--biosynthesis Dinoprostone--physiology Drug Synergism Granulocyte-Macrophage Colony-Stimulating Factor--biosynthesis Immunoglobulin E--physiology Interleukin-6--biosynthesis Kinetics Mast Cells--immunology Mice Mice, Inbred C57BL Protein Isoforms--biosynthesis Receptors, Prostaglandin E--biosynthesis Receptors, Prostaglandin E, EP1 Subtype Receptors, Prostaglandin E, EP3 Subtype Second Messenger Systems--physiology Up-Regulation--immunology beta-N-Acetylhexosaminidases--biosynthesis