TY  - GEN
AU  - Ostermann,N
AU  - Lavie,A
AU  - Padiyar,S
AU  - Brundiers,R
AU  - Veit,T
AU  - Reinstein,J
AU  - Goody,R S
AU  - Konrad,M
AU  - Schlichting,I
TI  - Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP
SN  - 0022-2836
PY  - 2000///1214
KW  - Anti-HIV Agents
KW  - metabolism
KW  - Binding Sites
KW  - Catalysis
KW  - Crystallography, X-Ray
KW  - Dideoxynucleotides
KW  - Enzyme Stability
KW  - Escherichia coli
KW  - enzymology
KW  - Humans
KW  - Kinetics
KW  - Models, Molecular
KW  - Mutation
KW  - genetics
KW  - Nucleoside-Phosphate Kinase
KW  - chemistry
KW  - Nucleotides
KW  - Phosphorylation
KW  - Prodrugs
KW  - Protein Binding
KW  - Protein Conformation
KW  - Recombinant Fusion Proteins
KW  - Thymine Nucleotides
KW  - Zidovudine
KW  - analogs & derivatives
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1006/jmbi.2000.4175
ER  -