Ostermann, N <br/><br/>
Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP.  [electronic resource] 

 -  Journal of molecular biology  Nov 2000 
 - 43-53 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0022-2836 
<br/><br/><label>Standard No.: </label>10.1006/jmbi.2000.4175  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Anti-HIV Agents--metabolism<br/>Binding Sites<br/>Catalysis<br/>Crystallography, X-Ray<br/>Dideoxynucleotides<br/>Enzyme Stability<br/>Escherichia coli--enzymology<br/>Humans<br/>Kinetics<br/>Models, Molecular<br/>Mutation--genetics<br/>Nucleoside-Phosphate Kinase--chemistry<br/>Nucleotides--metabolism<br/>Phosphorylation<br/>Prodrugs--metabolism<br/>Protein Binding<br/>Protein Conformation<br/>Recombinant Fusion Proteins--chemistry<br/>Thymine Nucleotides--metabolism<br/>Zidovudine--analogs & derivatives