TY - GEN AU - Kildsgaard,J AU - Hollmann,T J AU - Matthews,K W AU - Bian,K AU - Murad,F AU - Wetsel,R A TI - Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock SN - 0022-1767 PY - 2000///1222 KW - Amino Acid Sequence KW - Animals KW - Anti-Inflammatory Agents, Non-Steroidal KW - immunology KW - Complement C3a KW - metabolism KW - Dose-Response Relationship, Immunologic KW - Gene Targeting KW - methods KW - Genetic Predisposition to Disease KW - Injections, Intravenous KW - Interleukin-1 KW - biosynthesis KW - Lipopolysaccharides KW - toxicity KW - Membrane Proteins KW - Mice KW - Mice, Inbred C57BL KW - Mice, Inbred Strains KW - Mice, Knockout KW - Molecular Sequence Data KW - Mutagenesis, Insertional KW - Receptors, Complement KW - deficiency KW - Shock, Septic KW - genetics N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.4049/jimmunol.165.10.5406 ER -