Jacobs, J J

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. [electronic resource] - Nature genetics Nov 2000 - 291-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1061-4036

10.1038/81583 doi


Adenocarcinoma--genetics
Animals
Breast Neoplasms--genetics
COS Cells
Carrier Proteins--genetics
Cell Cycle Proteins--genetics
Cell Transformation, Neoplastic--genetics
Cells, Cultured
Cellular Senescence--genetics
Chromosomes, Human, Pair 17--genetics
Cyclin-Dependent Kinase Inhibitor p16
DNA-Binding Proteins
E2F Transcription Factors
E2F1 Transcription Factor
Female
Fibroblasts--cytology
Gene Amplification
Gene Deletion
Gene Expression Regulation, Neoplastic
Genes, BRCA1
Humans
Mice
Neoplasm Proteins--biosynthesis
Neoplastic Syndromes, Hereditary--genetics
Nuclear Proteins--genetics
Oncogenes
Polycomb Repressive Complex 1
Promoter Regions, Genetic
Protein Biosynthesis
Proteins--genetics
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-myc--antagonists & inhibitors
Proto-Oncogene Proteins p21(ras)--antagonists & inhibitors
Repressor Proteins--genetics
Retinoblastoma-Binding Protein 1
T-Box Domain Proteins--genetics
Transcription Factor DP1
Transcription Factors--antagonists & inhibitors
Transfection
Tumor Cells, Cultured
Tumor Suppressor Protein p14ARF