TY - GEN AU - Murdock,D G AU - Christacos,N C AU - Wallace,D C TI - The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method SN - 1362-4962 PY - 2000///1116 KW - Acidosis, Lactic KW - genetics KW - Adult KW - Aged KW - Aged, 80 and over KW - Aging KW - Brain KW - growth & development KW - DNA Mutational Analysis KW - methods KW - DNA, Mitochondrial KW - Epilepsies, Myoclonic KW - Female KW - Humans KW - Male KW - Middle Aged KW - Muscle Development KW - Muscle, Skeletal KW - Peptide Nucleic Acids KW - Plasmids KW - Point Mutation KW - Polymerase Chain Reaction KW - Promoter Regions, Genetic KW - RNA, Transfer, Leu KW - RNA, Transfer, Lys KW - Sensitivity and Specificity KW - Stroke KW - Templates, Genetic N1 - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1093/nar/28.21.4350 ER -