The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method. [electronic resource]
- Nucleic acids research Nov 2000
- 4350-5 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
1362-4962
10.1093/nar/28.21.4350 doi
Acidosis, Lactic--genetics Adult Aged Aged, 80 and over Aging--genetics Brain--growth & development DNA Mutational Analysis--methods DNA, Mitochondrial--genetics Epilepsies, Myoclonic--genetics Female Humans Male Middle Aged Muscle Development Muscle, Skeletal--growth & development Peptide Nucleic Acids--genetics Plasmids--genetics Point Mutation--genetics Polymerase Chain Reaction--methods Promoter Regions, Genetic--genetics RNA, Transfer, Leu--genetics RNA, Transfer, Lys--genetics Sensitivity and Specificity Stroke--genetics Templates, Genetic