TY - GEN AU - Yan,M AU - Wang,L C AU - Hymowitz,S G AU - Schilbach,S AU - Lee,J AU - Goddard,A AU - de Vos,A M AU - Gao,W Q AU - Dixit,V M TI - Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors SN - 0036-8075 PY - 2000///1107 KW - Amino Acid Sequence KW - Amino Acid Substitution KW - Animals KW - Binding Sites KW - Cell Line KW - DNA-Binding Proteins KW - metabolism KW - Ectodermal Dysplasia KW - genetics KW - Ectodysplasins KW - Epidermis KW - embryology KW - Humans KW - I-kappa B Proteins KW - In Situ Hybridization KW - Ligands KW - Membrane Proteins KW - chemistry KW - Mice KW - Models, Molecular KW - Molecular Sequence Data KW - Morphogenesis KW - NF-KappaB Inhibitor alpha KW - NF-kappa B KW - Phosphorylation KW - Point Mutation KW - Protein Conformation KW - Proteins KW - Receptors, Cell Surface KW - Recombinant Fusion Proteins KW - Signal Transduction KW - TNF Receptor-Associated Factor 6 KW - Transfection N1 - Publication Type: Journal Article UR - https://doi.org/10.1126/science.290.5491.523 ER -