Expression of the alpha 5 integrin subunit gene promoter is positively regulated by the extracellular matrix component fibronectin through the transcription factor Sp1 in corneal epithelial cells in vitro. [electronic resource]
- The Journal of biological chemistry Dec 2000
- 39182-92 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M002945200 doi
Animals Antigens, CD--genetics Base Sequence Blotting, Western Cell Line Cell Nucleus--metabolism Cells, Cultured Chloramphenicol O-Acetyltransferase--metabolism Cornea--metabolism DNA--metabolism Dose-Response Relationship, Drug Drosophila Electrophoresis, Polyacrylamide Gel Enzyme Inhibitors--pharmacology Epithelial Cells--metabolism Extracellular Matrix--metabolism Fibronectins--metabolism Flavonoids--pharmacology Gene Expression Regulation HeLa Cells Humans Integrin alpha5 Ligands MAP Kinase Kinase Kinase 1 Molecular Sequence Data Mutagenesis, Site-Directed Phosphorylation Plasmids--metabolism Promoter Regions, Genetic Protein Binding Protein Serine-Threonine Kinases--antagonists & inhibitors Rabbits Sequence Homology, Nucleic Acid Signal Transduction Sp1 Transcription Factor--metabolism Transfection