TY - GEN AU - Wurzer,G AU - Herceg,Z AU - Wesierska-Gadek,J TI - Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein SN - 0008-5472 PY - 2000///0831 KW - ATP Binding Cassette Transporter, Subfamily B, Member 1 KW - antagonists & inhibitors KW - Animals KW - Antineoplastic Agents KW - pharmacokinetics KW - Breast Neoplasms KW - drug therapy KW - Clone Cells KW - Dose-Response Relationship, Drug KW - Doxorubicin KW - Drug Resistance, Multiple KW - genetics KW - Drug Resistance, Neoplasm KW - Embryo, Mammalian KW - Fibroblasts KW - drug effects KW - Gene Expression Regulation KW - Gene Expression Regulation, Neoplastic KW - Humans KW - Mice KW - Mice, Knockout KW - Poly(ADP-ribose) Polymerases KW - deficiency KW - Probenecid KW - pharmacology KW - Tumor Cells, Cultured KW - Tumor Suppressor Protein p53 KW - biosynthesis KW - Up-Regulation KW - Verapamil N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't ER -