TY  - GEN
AU  - Jounaidi,Y
AU  - Waxman,D J
TI  - Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy
SN  - 0008-5472
PY  - 2000///0824
KW  - Animals
KW  - Antineoplastic Agents
KW  - administration & dosage
KW  - Antineoplastic Agents, Alkylating
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - therapeutic use
KW  - Body Weight
KW  - drug effects
KW  - Cell Division
KW  - Cyclophosphamide
KW  - Cytochrome P-450 Enzyme System
KW  - metabolism
KW  - Dose-Response Relationship, Drug
KW  - Gene Transfer Techniques
KW  - Genetic Vectors
KW  - Gliosarcoma
KW  - drug therapy
KW  - Humans
KW  - Hypoxia
KW  - Mice
KW  - Mice, SCID
KW  - NADH, NADPH Oxidoreductases
KW  - NADPH-Ferrihemoprotein Reductase
KW  - Neoplasm Transplantation
KW  - Oxygen
KW  - Prodrugs
KW  - pharmacology
KW  - Retroviridae
KW  - Time Factors
KW  - Tirapazamine
KW  - Transduction, Genetic
KW  - Triazines
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
ER  -