TY - GEN AU - Dinter,H AU - Tse,J AU - Halks-Miller,M AU - Asarnow,D AU - Onuffer,J AU - Faulds,D AU - Mitrovic,B AU - Kirsch,G AU - Laurent,H AU - Esperling,P AU - Seidelmann,D AU - Ottow,E AU - Schneider,H AU - Tuohy,V K AU - Wachtel,H AU - Perez,H D TI - The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents SN - 0165-5728 PY - 2000///0825 KW - 3',5'-Cyclic-AMP Phosphodiesterases KW - antagonists & inhibitors KW - Acute Disease KW - Animals KW - Anti-Inflammatory Agents KW - pharmacology KW - Cell Division KW - drug effects KW - Cells, Cultured KW - Central Nervous System KW - Chronic Disease KW - Cyclic Nucleotide Phosphodiesterases, Type 4 KW - Dose-Response Relationship, Drug KW - Down-Regulation KW - Encephalomyelitis, Autoimmune, Experimental KW - drug therapy KW - Enzyme Inhibitors KW - Female KW - Humans KW - Inflammation KW - Interferon-gamma KW - biosynthesis KW - Interleukin-5 KW - Lymphocyte Activation KW - Mice KW - Mice, Inbred Strains KW - Multiple Sclerosis KW - Oxazoles KW - Rats KW - Rats, Inbred Lew KW - Recurrence KW - Spleen KW - Substrate Specificity KW - Th1 Cells KW - cytology KW - Th2 Cells KW - Tumor Necrosis Factor-alpha KW - metabolism N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/s0165-5728(00)00265-4 ER -