TY - GEN AU - Rothwell,D G AU - Hang,B AU - Gorman,M A AU - Freemont,P S AU - Singer,B AU - Hickson,I D TI - Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding SN - 1362-4962 PY - 2000///0718 KW - Benzoquinones KW - metabolism KW - Binding Sites KW - Carbon-Oxygen Lyases KW - chemistry KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - DNA-Binding Proteins KW - genetics KW - Escherichia coli KW - Humans KW - Hydrogen Bonding KW - Kinetics KW - Models, Molecular KW - Mutation KW - Oligodeoxyribonucleotides KW - Protein Structure, Secondary KW - Substrate Specificity N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1093/nar/28.11.2207 ER -