TY  - GEN
AU  - Li,T K
AU  - Bathory,E
AU  - LaVoie,E J
AU  - Srinivasan,A R
AU  - Olson,W K
AU  - Sauers,R R
AU  - Liu,L F
AU  - Pilch,D S
TI  - Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions
SN  - 0006-2960
PY  - 2000///0721
KW  - Antioxidants
KW  - pharmacology
KW  - Berberine Alkaloids
KW  - chemistry
KW  - DNA
KW  - DNA Topoisomerases, Type I
KW  - DNA Topoisomerases, Type II
KW  - Humans
KW  - Intercalating Agents
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Nucleic Acid Conformation
KW  - drug effects
KW  - Nucleic Acid Denaturation
KW  - Protein Binding
KW  - Temperature
KW  - Thermodynamics
KW  - Viscosity
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1021/bi000171g
ER  -