Owen, M R <br/><br/>
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.  [electronic resource] 

 -  The Biochemical journal  Jun 2000 
 - 607-14 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0264-6021 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Electron Transport--drug effects<br/>Electron Transport Complex I<br/>Gluconeogenesis--drug effects<br/>Hypoglycemic Agents--pharmacology<br/>Liver--drug effects<br/>Male<br/>Metformin--pharmacology<br/>Mitochondria--drug effects<br/>NADH, NADPH Oxidoreductases--antagonists & inhibitors<br/>Rats<br/>Rats, Wistar<br/>Signal Transduction<br/>Submitochondrial Particles--enzymology<br/>Tumor Cells, Cultured