TY  - GEN
AU  - Schmidt,A
AU  - Wu,H
AU  - MacKenzie,R E
AU  - Chen,V J
AU  - Bewly,J R
AU  - Ray,J E
AU  - Toth,J E
AU  - Cygler,M
TI  - Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase
SN  - 0006-2960
PY  - 2000///0711
KW  - Amino Acid Sequence
KW  - Aminohydrolases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Binding Sites
KW  - Crystallography, X-Ray
KW  - Drosophila
KW  - Escherichia coli
KW  - enzymology
KW  - Folic Acid Antagonists
KW  - chemistry
KW  - Humans
KW  - Methylenetetrahydrofolate Dehydrogenase (NADP)
KW  - Mice
KW  - Models, Molecular
KW  - Molecular Sequence Data
KW  - Multienzyme Complexes
KW  - Mutagenesis, Site-Directed
KW  - NADP
KW  - metabolism
KW  - Protein Conformation
KW  - Rats
KW  - Recombinant Proteins
KW  - Sequence Alignment
KW  - Sequence Homology, Amino Acid
KW  - Structure-Activity Relationship
KW  - Tetrahydrofolates
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/bi992734y
ER  -