Busby, E C <br/><br/>
The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.  [electronic resource] 

 -  Cancer research  Apr 2000 
 - 2108-12 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0008-5472 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alkaloids--pharmacology<br/>Antineoplastic Agents--pharmacology<br/>Cell Cycle Proteins--metabolism<br/>Checkpoint Kinase 1<br/>Checkpoint Kinase 2<br/>DNA Damage--drug effects<br/>G2 Phase--drug effects<br/>Humans<br/>Inhibitory Concentration 50<br/>K562 Cells<br/>Models, Biological<br/>Phosphorylation--drug effects<br/>Phosphoserine--metabolism<br/>Protein Kinase Inhibitors<br/>Protein Kinases--metabolism<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Radiation-Sensitizing Agents--pharmacology<br/>Signal Transduction--drug effects<br/>Staurosporine--analogs & derivatives<br/>cdc25 Phosphatases--metabolism