Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. [electronic resource]
- The Journal of biological chemistry Jun 2000
- 19831-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M001475200 doi
Amino Acid Sequence Animals Apoptosis--drug effects Binding Sites Blotting, Western Carcinogens--pharmacology Caspase 3 Caspase 6 Caspase Inhibitors Caspases--metabolism Cell Line Enzyme Activation--genetics Fluorescent Antibody Technique Humans Huntingtin Protein Molecular Sequence Data Mutagenesis Nerve Tissue Proteins--genetics Neurons--metabolism Nuclear Proteins--genetics Peptides--metabolism Plasmids--metabolism Rats Tamoxifen--pharmacology Time Factors Transfection