TY  - GEN
AU  - Fowler,S M
AU  - Riley,R J
AU  - Pritchard,M P
AU  - Sutcliffe,M J
AU  - Friedberg,T
AU  - Wolf,C R
TI  - Amino acid 305 determines catalytic center accessibility in CYP3A4
SN  - 0006-2960
PY  - 2000///0616
KW  - Alanine
KW  - genetics
KW  - Amino Acid Substitution
KW  - Aryl Hydrocarbon Hydroxylases
KW  - Binding Sites
KW  - Catalysis
KW  - drug effects
KW  - Clotrimazole
KW  - pharmacology
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - chemistry
KW  - Diazepam
KW  - metabolism
KW  - Econazole
KW  - Erythromycin
KW  - Humans
KW  - Imidazoles
KW  - Ketoconazole
KW  - Kinetics
KW  - Miconazole
KW  - Mixed Function Oxygenases
KW  - antagonists & inhibitors
KW  - Multienzyme Complexes
KW  - Mutation
KW  - Nifedipine
KW  - Oxidoreductases, N-Demethylating
KW  - Substrate Specificity
KW  - Testosterone
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/bi992372u
ER  -