Fowler, S M <br/><br/>
Amino acid 305 determines catalytic center accessibility in CYP3A4.  [electronic resource] 

 -  Biochemistry  Apr 2000 
 - 4406-14 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0006-2960 
<br/><br/><label>Standard No.: </label>10.1021/bi992372u  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alanine--genetics<br/>Amino Acid Substitution--genetics<br/>Aryl Hydrocarbon Hydroxylases<br/>Binding Sites<br/>Catalysis--drug effects<br/>Clotrimazole--pharmacology<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 Enzyme Inhibitors<br/>Cytochrome P-450 Enzyme System--chemistry<br/>Diazepam--metabolism<br/>Econazole--pharmacology<br/>Erythromycin--metabolism<br/>Humans<br/>Imidazoles--chemistry<br/>Ketoconazole--metabolism<br/>Kinetics<br/>Miconazole--pharmacology<br/>Mixed Function Oxygenases--antagonists & inhibitors<br/>Multienzyme Complexes--antagonists & inhibitors<br/>Mutation--genetics<br/>Nifedipine--metabolism<br/>Oxidoreductases, N-Demethylating--antagonists & inhibitors<br/>Substrate Specificity<br/>Testosterone--metabolism