Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal-regulated kinase ERK1. [electronic resource]
- Cancer research Mar 2000
- 1720-8 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0008-5472
3T3 Cells Amino Acid Sequence Animals Base Sequence COS Cells Cell Extracts--chemistry Cell Line Cricetinae Escherichia coli--enzymology Gene Expression Regulation Genetic Complementation Test Guanosine Diphosphate--metabolism Guanosine Triphosphate--metabolism Humans Mesocricetus Mice Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases--metabolism Molecular Sequence Data Oncogene Proteins--genetics Protein Biosynthesis Pyrophosphatases--metabolism Recombinant Fusion Proteins--genetics Saccharomyces cerevisiae--genetics Sequence Homology, Amino Acid Transcription, Genetic Transfection Tumor Cells, Cultured ras Proteins--metabolism