TY - GEN AU - Zhong,H AU - Chiles,K AU - Feldser,D AU - Laughner,E AU - Hanrahan,C AU - Georgescu,M M AU - Simons,J W AU - Semenza,G L TI - Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics SN - 0008-5472 PY - 2000///0504 KW - Carrier Proteins KW - Chromones KW - pharmacology KW - Culture Media, Serum-Free KW - DNA-Binding Proteins KW - biosynthesis KW - Endothelial Growth Factors KW - Enzyme Inhibitors KW - Enzyme-Linked Immunosorbent Assay KW - Epidermal Growth Factor KW - genetics KW - Humans KW - Hypoxia KW - physiopathology KW - Hypoxia-Inducible Factor 1 KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Immunophilins KW - Lymphokines KW - Male KW - Morpholines KW - Neovascularization, Pathologic KW - metabolism KW - Nuclear Proteins KW - PTEN Phosphohydrolase KW - Phosphatidylinositol 3-Kinases KW - Phosphoinositide-3 Kinase Inhibitors KW - Phosphoric Monoester Hydrolases KW - Phosphotransferases (Alcohol Group Acceptor) KW - Prostatic Neoplasms KW - drug therapy KW - Protein Serine-Threonine Kinases KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-akt KW - Signal Transduction KW - drug effects KW - TOR Serine-Threonine Kinases KW - Tetradecanoylphorbol Acetate KW - Transcription Factors KW - Tumor Cells, Cultured KW - Tumor Suppressor Proteins KW - Vascular Endothelial Growth Factor A KW - Vascular Endothelial Growth Factors N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S ER -