TY  - GEN
AU  - Uckun,F M
AU  - Mao,C
AU  - Vassilev,A O
AU  - Huang,H
AU  - Jan,S T
TI  - Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1
SN  - 0960-894X
PY  - 2000///0613
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Breast Neoplasms
KW  - pathology
KW  - Crystallography, X-Ray
KW  - Drug Design
KW  - Ethers, Cyclic
KW  - chemistry
KW  - Humans
KW  - Lactones
KW  - Macrolides
KW  - Mitosis
KW  - drug effects
KW  - Models, Molecular
KW  - Nephelometry and Turbidimetry
KW  - Porifera
KW  - Pyrans
KW  - Spiro Compounds
KW  - Structure-Activity Relationship
KW  - Tubulin
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/s0960-894x(00)00044-5
ER  -