Uckun, F M <br/><br/>
Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Mar 2000 
 - 541-5 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0960-894X 
<br/><br/><label>Standard No.: </label>10.1016/s0960-894x(00)00044-5  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Breast Neoplasms--pathology<br/>Crystallography, X-Ray<br/>Drug Design<br/>Ethers, Cyclic--chemistry<br/>Humans<br/>Lactones--chemistry<br/>Macrolides<br/>Mitosis--drug effects<br/>Models, Molecular<br/>Nephelometry and Turbidimetry<br/>Porifera--chemistry<br/>Pyrans--chemical synthesis<br/>Spiro Compounds--chemical synthesis<br/>Structure-Activity Relationship<br/>Tubulin--drug effects<br/>Tumor Cells, Cultured