TY - GEN AU - Gambhir,S S AU - Bauer,E AU - Black,M E AU - Liang,Q AU - Kokoris,M S AU - Barrio,J R AU - Iyer,M AU - Namavari,M AU - Phelps,M E AU - Herschman,H R TI - A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography SN - 0027-8424 PY - 2000///0425 KW - Acyclovir KW - metabolism KW - Adenoviridae KW - Animals KW - Antiviral Agents KW - Blotting, Northern KW - Blotting, Western KW - Chromatography, High Pressure Liquid KW - Escherichia coli KW - Fluorine KW - pharmacokinetics KW - Ganciclovir KW - Genes, Reporter KW - Herpesvirus 1, Human KW - enzymology KW - Liver KW - Mice KW - Mutagenesis KW - Prodrugs KW - Rats KW - Thymidine Kinase KW - genetics KW - Time Factors KW - Tomography, Emission-Computed KW - methods KW - Transfection KW - Tumor Cells, Cultured N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1073/pnas.97.6.2785 ER -