TY - GEN AU - Runkel,L AU - deDios,C AU - Karpusas,M AU - Betzenhauser,M AU - Muldowney,C AU - Zafari,M AU - Benjamin,C D AU - Miller,S AU - Hochman,P S AU - Whitty,A TI - Systematic mutational mapping of sites on human interferon-beta-1a that are important for receptor binding and functional activity SN - 0006-2960 PY - 2000///0419 KW - Alanine KW - genetics KW - Amino Acid Sequence KW - Amino Acid Substitution KW - Animals KW - Antiviral Agents KW - metabolism KW - COS Cells KW - DNA Mutational Analysis KW - Genetic Vectors KW - Growth Inhibitors KW - physiology KW - Humans KW - Interferon beta-1a KW - Interferon-beta KW - biosynthesis KW - Membrane Proteins KW - Molecular Sequence Data KW - Mutagenesis, Site-Directed KW - Peptide Mapping KW - Protein Binding KW - Protein Structure, Tertiary KW - Receptor, Interferon alpha-beta KW - Receptors, Interferon KW - Structure-Activity Relationship KW - Tumor Cells, Cultured N1 - Publication Type: Journal Article UR - https://doi.org/10.1021/bi991631c ER -