TY  - GEN
AU  - Pink,J J
AU  - Planchon,S M
AU  - Tagliarino,C
AU  - Varnes,M E
AU  - Siegel,D
AU  - Boothman,D A
TI  - NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity
SN  - 0021-9258
PY  - 2000///0330
KW  - Antibiotics, Antineoplastic
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Blotting, Western
KW  - Breast Neoplasms
KW  - drug therapy
KW  - Cell Division
KW  - Cytochrome Reductases
KW  - metabolism
KW  - Cytochrome-B(5) Reductase
KW  - Dicumarol
KW  - Dose-Response Relationship, Drug
KW  - Drug Synergism
KW  - Enzyme Inhibitors
KW  - Flow Cytometry
KW  - Humans
KW  - Models, Biological
KW  - NAD
KW  - NADH, NADPH Oxidoreductases
KW  - NADPH-Ferrihemoprotein Reductase
KW  - Naphthoquinones
KW  - Proteins
KW  - Quinone Reductases
KW  - Transfection
KW  - Tumor Cells, Cultured
KW  - Tumor Suppressor Protein p53
KW  - Vitamin K
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1074/jbc.275.8.5416
ER  -