TY  - GEN
AU  - Skovronsky,D M
AU  - Pijak,D S
AU  - Doms,R W
AU  - Lee,V M
TI  - A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP
SN  - 0006-2960
PY  - 2000///0223
KW  - Acetylcysteine
KW  - analogs & derivatives
KW  - Amyloid Precursor Protein Secretases
KW  - Amyloid beta-Peptides
KW  - antagonists & inhibitors
KW  - Amyloid beta-Protein Precursor
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Binding, Competitive
KW  - CHO Cells
KW  - Cell Compartmentation
KW  - Cricetinae
KW  - Cysteine Endopeptidases
KW  - metabolism
KW  - Cysteine Proteinase Inhibitors
KW  - pharmacology
KW  - Endopeptidases
KW  - Endoplasmic Reticulum
KW  - drug effects
KW  - Humans
KW  - Hydrolysis
KW  - Intracellular Fluid
KW  - Leupeptins
KW  - Multienzyme Complexes
KW  - Neurons
KW  - Peptide Fragments
KW  - Proteasome Endopeptidase Complex
KW  - Recombinant Fusion Proteins
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1021/bi991728z
ER  -