TY - GEN AU - Zhao,R AU - Gao,F AU - Wang,P J AU - Goldman,I D TI - Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis SN - 0026-895X PY - 2000///0302 KW - Amino Acid Substitution KW - Animals KW - Anions KW - metabolism KW - Antimetabolites, Antineoplastic KW - pharmacology KW - Biological Transport KW - Carrier Proteins KW - genetics KW - Folic Acid KW - Glutamic Acid KW - Leucovorin KW - Leukemia L1210 KW - Membrane Proteins KW - Membrane Transport Proteins KW - Methotrexate KW - Mice KW - Mutagenesis, Site-Directed KW - Reduced Folate Carrier Protein KW - Tetrahydrofolates KW - Transfection KW - Tumor Cells, Cultured N1 - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S ER -