Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). [electronic resource]
- Blood Feb 2000
- 1014-22 p. digital
Publication Type: Journal Article
0006-4971
ATP Binding Cassette Transporter, Subfamily B, Member 1--biosynthesis ATP-Binding Cassette Transporters--biosynthesis Acetylation--drug effects Antineoplastic Agents--pharmacology Apoptosis--drug effects Apoptotic Protease-Activating Factor 1 Arsenic Trioxide Arsenicals--pharmacology Caspases--metabolism Cytochrome c Group--metabolism Cytosol--metabolism Drug Resistance, Multiple Drug Resistance, Neoplasm Fas Ligand Protein Fusion Proteins, bcr-abl--biosynthesis Gene Expression Regulation, Leukemic Genes, bcl-2 HL-60 Cells--drug effects Histones--metabolism Humans Immunophenotyping K562 Cells--drug effects Leukemia, Myelogenous, Chronic, BCR-ABL Positive--genetics Macrophage-1 Antigen--biosynthesis Membrane Glycoproteins--biosynthesis Mitochondria--metabolism Multidrug Resistance-Associated Proteins Neoplasm Proteins--biosynthesis Oxides--pharmacology Protein Biosynthesis Protein Processing, Post-Translational--drug effects Proteins--genetics Proto-Oncogene Proteins--biosynthesis Proto-Oncogene Proteins c-bcl-2--biosynthesis bcl-2-Associated X Protein bcl-X Protein fas Receptor--biosynthesis