Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms. [electronic resource]
- The Journal of pharmacology and experimental therapeutics Feb 2000
- 618-28 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0022-3565
Animals Antibodies--pharmacology Aryl Hydrocarbon Hydroxylases Biotransformation Blotting, Western Chromatography, High Pressure Liquid Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System--immunology Dose-Response Relationship, Drug Humans Immunochemistry In Vitro Techniques Inhibitory Concentration 50 Ketoconazole--pharmacology Mice Microsomes, Liver--metabolism Midazolam--pharmacokinetics Mixed Function Oxygenases--immunology Oxidoreductases, N-Demethylating--physiology Protein Isoforms--physiology Species Specificity Steroid 16-alpha-Hydroxylase Steroid Hydroxylases--immunology Triazolam--pharmacokinetics