Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis. [electronic resource]
- The Journal of biological chemistry Jan 2000
- 2103-14 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.275.3.2103 doi
Activating Transcription Factor 2 Animals CCAAT-Enhancer-Binding Proteins CHO Cells Cell Division--drug effects Cricetinae Cyclic AMP Response Element-Binding Protein--metabolism Cytoskeleton--enzymology DNA-Binding Proteins--metabolism Dose-Response Relationship, Drug Enzyme Activation Enzyme Inhibitors--pharmacology Human Growth Hormone--pharmacology Humans Janus Kinase 2 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases--genetics Phosphorylation Protein-Tyrosine Kinases--genetics Proto-Oncogene Proteins--metabolism Rats Time Factors Transcription Factor CHOP Transcription Factors--metabolism Transcription, Genetic Transcriptional Activation Transfection ets-Domain Protein Elk-1 p38 Mitogen-Activated Protein Kinases