TY  - GEN
AU  - Pascal,Y
AU  - Andrianjara,C R
AU  - Auclair,E
AU  - Avenel,N
AU  - Bertin,B
AU  - Calvet,A
AU  - Féru,F
AU  - Lardon,S
AU  - Moodley,I
AU  - Ouagued,M
AU  - Payne,A
AU  - Pruniaux,M P
AU  - Szilagyi,C
TI  - Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors
SN  - 0960-894X
PY  - 2000///0228
KW  - 3',5'-Cyclic-AMP Phosphodiesterases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Benzodiazepines
KW  - chemical synthesis
KW  - Binding Sites
KW  - Cyclic Nucleotide Phosphodiesterases, Type 4
KW  - Dogs
KW  - Guinea Pigs
KW  - Humans
KW  - Indoles
KW  - Inhibitory Concentration 50
KW  - Phosphodiesterase Inhibitors
KW  - Rats
KW  - Rats, Inbred BN
KW  - Rats, Wistar
KW  - Rolipram
KW  - metabolism
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Substrate Specificity
KW  - U937 Cells
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/s0960-894x(99)00573-9
ER  -