TY  - GEN
AU  - Cummings,C J
AU  - Reinstein,E
AU  - Sun,Y
AU  - Antalffy,B
AU  - Jiang,Y
AU  - Ciechanover,A
AU  - Orr,H T
AU  - Beaudet,A L
AU  - Zoghbi,H Y
TI  - Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice
SN  - 0896-6273
PY  - 2000///0127
KW  - Animals
KW  - Ataxin-1
KW  - Ataxins
KW  - Cell Nucleus
KW  - genetics
KW  - Cells, Cultured
KW  - Cysteine Endopeptidases
KW  - metabolism
KW  - Fluorescent Antibody Technique
KW  - HeLa Cells
KW  - Humans
KW  - Immunoblotting
KW  - Immunohistochemistry
KW  - Inclusion Bodies
KW  - Ligases
KW  - deficiency
KW  - Mice
KW  - Mice, Knockout
KW  - Microscopy, Confocal
KW  - Multienzyme Complexes
KW  - Mutation
KW  - physiology
KW  - Nerve Tissue Proteins
KW  - biosynthesis
KW  - Nuclear Proteins
KW  - Peptides
KW  - toxicity
KW  - Phenotype
KW  - Plasmids
KW  - Proteasome Endopeptidase Complex
KW  - Purkinje Cells
KW  - Spinocerebellar Degenerations
KW  - Ubiquitin-Protein Ligases
KW  - Ubiquitins
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1016/s0896-6273(00)81035-1
ER  -