TY - GEN AU - Landree,M A AU - Wibbenmeyer,J A AU - Roth,D B TI - Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination SN - 0890-9369 PY - 2000///0111 KW - Amino Acid Sequence KW - Amino Acid Substitution KW - Animals KW - Binding Sites KW - CHO Cells KW - Catalysis KW - Catalytic Domain KW - Cricetinae KW - Cricetulus KW - Cysteine KW - chemistry KW - DNA KW - genetics KW - DNA Nucleotidyltransferases KW - metabolism KW - DNA-Binding Proteins KW - Gene Rearrangement KW - physiology KW - Homeodomain Proteins KW - Humans KW - Lymphocytes KW - Manganese KW - Molecular Sequence Data KW - Mutagenesis, Site-Directed KW - Nuclear Proteins KW - Recombinant Fusion Proteins KW - Sequence Alignment KW - Sequence Homology, Amino Acid KW - Structure-Activity Relationship KW - Transfection KW - VDJ Recombinases KW - Vertebrates N1 - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1101/gad.13.23.3059 ER -