TY - GEN AU - Chen,G AU - Templeton,D AU - Suttle,D P AU - Stacey,D W TI - Ras stimulates DNA topoisomerase II alpha through MEK: a link between oncogenic signaling and a therapeutic target SN - 0950-9232 PY - 2000///0104 KW - 3T3 Cells KW - Animals KW - Antibodies KW - administration & dosage KW - Antigens, Neoplasm KW - Binding Sites KW - DNA Topoisomerases, Type II KW - genetics KW - DNA-Binding Proteins KW - Enzyme Activation KW - Isoenzymes KW - MAP Kinase Kinase Kinase 1 KW - MAP Kinase Kinase Kinases KW - metabolism KW - Mice KW - Microinjections KW - Promoter Regions, Genetic KW - Protein Serine-Threonine Kinases KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-ets KW - Proto-Oncogene Proteins p21(ras) KW - antagonists & inhibitors KW - Signal Transduction KW - Transcription Factors KW - Transcriptional Activation N1 - Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1038/sj.onc.1203149 ER -