TY - GEN AU - Schmidtke,G AU - Holzhütter,H G AU - Bogyo,M AU - Kairies,N AU - Groll,M AU - de Giuli,R AU - Emch,S AU - Groettrup,M TI - How an inhibitor of the HIV-I protease modulates proteasome activity SN - 0021-9258 PY - 2000///0113 KW - Animals KW - Binding Sites KW - Canavanine KW - pharmacology KW - Cell Line KW - Cysteine Endopeptidases KW - chemistry KW - Cytomegalovirus KW - HIV Protease Inhibitors KW - HIV-1 KW - enzymology KW - Humans KW - Immediate-Early Proteins KW - metabolism KW - Iodine Radioisotopes KW - Kinetics KW - Mice KW - Models, Molecular KW - Multienzyme Complexes KW - Oligopeptides KW - pharmacokinetics KW - Proteasome Endopeptidase Complex KW - Protein Conformation KW - Protein Structure, Quaternary KW - Ritonavir KW - Saccharomyces cerevisiae KW - Sulfones KW - Ubiquitins N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1074/jbc.274.50.35734 ER -