TY  - GEN
AU  - Lagu,B
AU  - Tian,D
AU  - Nagarathnam,D
AU  - Marzabadi,M R
AU  - Wong,W C
AU  - Miao,S W
AU  - Zhang,F
AU  - Sun,W
AU  - Chiu,G
AU  - Fang,J
AU  - Forray,C
AU  - Chang,R S
AU  - Ransom,R W
AU  - Chen,T B
AU  - O'Malley,S
AU  - Zhang,K
AU  - Vyas,K P
AU  - Gluchowski,C
TI  - Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains
SN  - 0022-2623
PY  - 1999///1217
KW  - Adrenergic alpha-Antagonists
KW  - chemical synthesis
KW  - Animals
KW  - Binding, Competitive
KW  - Biological Availability
KW  - Dogs
KW  - Drug Design
KW  - GTP-Binding Proteins
KW  - metabolism
KW  - Half-Life
KW  - Humans
KW  - In Vitro Techniques
KW  - Male
KW  - Piperazines
KW  - Prostate
KW  - Pyrimidinones
KW  - Rats
KW  - Receptors, Adrenergic, alpha-1
KW  - Receptors, Opioid, mu
KW  - agonists
KW  - Recombinant Proteins
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm990202+
ER  -