TY  - GEN
AU  - Fiorani,P
AU  - Amatruda,J F
AU  - Silvestri,A
AU  - Butler,R H
AU  - Bjornsti,M A
AU  - Benedetti,P
TI  - Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity
SN  - 0026-895X
PY  - 1999///1217
KW  - Alanine
KW  - genetics
KW  - Amino Acid Substitution
KW  - Camptothecin
KW  - pharmacology
KW  - Catalysis
KW  - DNA
KW  - drug effects
KW  - DNA Topoisomerases, Type I
KW  - chemistry
KW  - Drug Resistance
KW  - Enzyme Inhibitors
KW  - Enzyme Stability
KW  - Glycine
KW  - Humans
KW  - Models, Molecular
KW  - Mutation
KW  - Protein Conformation
KW  - Protein Structure, Tertiary
KW  - Saccharomyces cerevisiae
KW  - Threonine
KW  - Topoisomerase I Inhibitors
KW  - Transfection
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1124/mol.56.6.1105
ER  -