Nishiyama, M

Low-dose cisplatin and 5-fluorouracil in combination can repress increased gene expression of cellular resistance determinants to themselves. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Sep 1999 - 2620-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1078-0432


ATP-Binding Cassette Transporters--biosynthesis
Adenocarcinoma--drug therapy
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Carcinoma, Renal Cell--drug therapy
Cisplatin--administration & dosage
Dihydrouracil Dehydrogenase (NADP)
Dose-Response Relationship, Drug
Drug Resistance, Multiple--genetics
Drug Resistance, Neoplasm--genetics
Drug Synergism
Fluorouracil--administration & dosage
Gastrointestinal Neoplasms--drug therapy
Gene Expression Regulation, Neoplastic--drug effects
Glutathione S-Transferase pi
Glutathione Transferase--biosynthesis
Humans
Isoenzymes--biosynthesis
K562 Cells--drug effects
Kidney Neoplasms--drug therapy
Multidrug Resistance-Associated Proteins
Neoplasm Proteins--biosynthesis
Oxidoreductases--biosynthesis
Thymidylate Synthase--genetics
Tumor Cells, Cultured