TY  - GEN
AU  - Kelly,S L
AU  - Lamb,D C
AU  - Loeffler,J
AU  - Einsele,H
AU  - Kelly,D E
TI  - The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity
SN  - 0006-291X
PY  - 1999///0923
KW  - Amino Acid Sequence
KW  - Amino Acid Substitution
KW  - Antifungal Agents
KW  - metabolism
KW  - Candida albicans
KW  - drug effects
KW  - Carbon Monoxide
KW  - Catalysis
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - chemistry
KW  - Drug Resistance, Microbial
KW  - Ergosterol
KW  - biosynthesis
KW  - Fluconazole
KW  - Heme
KW  - Inhibitory Concentration 50
KW  - Kinetics
KW  - Mutagenesis, Site-Directed
KW  - Oxidation-Reduction
KW  - Oxidoreductases
KW  - antagonists & inhibitors
KW  - Protein Binding
KW  - Saccharomyces cerevisiae
KW  - genetics
KW  - Spectrum Analysis
KW  - Sterol 14-Demethylase
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1006/bbrc.1999.1136
ER  -