Kelly, S L <br/><br/>
The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity.  [electronic resource] 

 -  Biochemical and biophysical research communications  Aug 1999 
 - 174-9 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0006-291X 
<br/><br/><label>Standard No.: </label>10.1006/bbrc.1999.1136  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Amino Acid Substitution<br/>Antifungal Agents--metabolism<br/>Candida albicans--drug effects<br/>Carbon Monoxide--metabolism<br/>Catalysis<br/>Cytochrome P-450 Enzyme Inhibitors<br/>Cytochrome P-450 Enzyme System--chemistry<br/>Drug Resistance, Microbial<br/>Ergosterol--biosynthesis<br/>Fluconazole--metabolism<br/>Heme--chemistry<br/>Inhibitory Concentration 50<br/>Kinetics<br/>Mutagenesis, Site-Directed<br/>Oxidation-Reduction<br/>Oxidoreductases--antagonists & inhibitors<br/>Protein Binding<br/>Saccharomyces cerevisiae--genetics<br/>Spectrum Analysis<br/>Sterol 14-Demethylase