TY  - GEN
AU  - Wessel,I
AU  - Jensen,L H
AU  - Jensen,P B
AU  - Falck,J
AU  - Rose,A
AU  - Roerth,M
AU  - Nitiss,J L
AU  - Sehested,M
TI  - Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform
SN  - 0008-5472
PY  - 1999///0812
KW  - Adenosine Triphosphate
KW  - metabolism
KW  - Amino Acid Sequence
KW  - Amino Acid Substitution
KW  - Amsacrine
KW  - pharmacology
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemistry
KW  - Binding Sites
KW  - CHO Cells
KW  - Carcinoma, Small Cell
KW  - drug therapy
KW  - Catalysis
KW  - drug effects
KW  - Consensus Sequence
KW  - Cricetinae
KW  - Cricetulus
KW  - DNA Damage
KW  - DNA Mutational Analysis
KW  - DNA Topoisomerases, Type II
KW  - genetics
KW  - DNA, Neoplasm
KW  - DNA, Single-Stranded
KW  - Drug Resistance, Neoplasm
KW  - Enzyme Inhibitors
KW  - Etoposide
KW  - Humans
KW  - Lung Neoplasms
KW  - Molecular Sequence Data
KW  - Mutagenesis, Site-Directed
KW  - Point Mutation
KW  - Protein Isoforms
KW  - antagonists & inhibitors
KW  - Razoxane
KW  - Recombinant Fusion Proteins
KW  - Saccharomyces cerevisiae
KW  - Structure-Activity Relationship
KW  - Thiobarbiturates
KW  - Topoisomerase II Inhibitors
KW  - Tumor Stem Cell Assay
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
ER  -