TY  - GEN
AU  - Higashikawa,F
AU  - Murakami,T
AU  - Kaneda,T
AU  - Takano,M
TI  - In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats
SN  - 0022-3573
PY  - 1999///0803
KW  - Administration, Oral
KW  - Animals
KW  - Anti-Anxiety Agents
KW  - pharmacokinetics
KW  - Aryl Hydrocarbon Hydroxylases
KW  - Clotrimazole
KW  - pharmacology
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme System
KW  - metabolism
KW  - Dexamethasone
KW  - Enzyme Activation
KW  - drug effects
KW  - In Vitro Techniques
KW  - Intestinal Mucosa
KW  - Liver
KW  - enzymology
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Microsomes, Liver
KW  - Midazolam
KW  - Oxidoreductases, N-Demethylating
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Substrate Specificity
KW  - Time Factors
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1211/0022357991772600
ER  -