Higashikawa, F <br/><br/>
In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats.  [electronic resource] 

 -  The Journal of pharmacy and pharmacology  Apr 1999 
 - 405-10 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-3573 
<br/><br/><label>Standard No.: </label>10.1211/0022357991772600  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Anti-Anxiety Agents--pharmacokinetics<br/>Aryl Hydrocarbon Hydroxylases<br/>Clotrimazole--pharmacology<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 Enzyme System--metabolism<br/>Dexamethasone--pharmacology<br/>Enzyme Activation--drug effects<br/>In Vitro Techniques<br/>Intestinal Mucosa--metabolism<br/>Liver--enzymology<br/>Male<br/>Metabolic Clearance Rate<br/>Microsomes, Liver--metabolism<br/>Midazolam--metabolism<br/>Oxidoreductases, N-Demethylating--metabolism<br/>Rats<br/>Rats, Sprague-Dawley<br/>Substrate Specificity<br/>Time Factors