TY  - GEN
AU  - Dehal,S S
AU  - Kupfer,D
TI  - Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins
SN  - 0090-9556
PY  - 1999///0716
KW  - Animals
KW  - Biotransformation
KW  - Catechols
KW  - metabolism
KW  - Cytochrome P-450 CYP2D6
KW  - biosynthesis
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme System
KW  - Estrogen Antagonists
KW  - pharmacokinetics
KW  - Humans
KW  - Hydroxylation
KW  - In Vitro Techniques
KW  - Liver
KW  - drug effects
KW  - Mixed Function Oxygenases
KW  - Pentobarbital
KW  - pharmacology
KW  - Protein Binding
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Tamoxifen
KW  - analogs & derivatives
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S
ER  -